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Thus, selenium supplementation and GPx-1 overexpression were found to reduce DNA damage, as measured by micronuclei formation, and enhance cell survival in response to UV-irradiation (22), whereas knockdown of GPx-1 was found to increase UV-induced damage (21)

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This dimeric state is stabilized by a zinc ion, playing a crucial role in maintaining the structural integrity and interaction of the two monomers [464]

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