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Additionally, there is a known immune exhaustion process that occurs between the second and third year of illness in ME/CFS, with test results for cytokines being different between patients who have been sick for shorter durations (less than 2 years) than for those who have been sick for longer durations 43

doi: 10.1074/jbc.274.42.30059

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Surprisingly, no reduction in the amount of hepatic lipofuscin was observed in the KO mice on HFD when compared to the control counterparts (Fig