Blouin M, Hodson ME, Delgado EA, Baker G, Brussaard L, Butt KR, Dai J, Dendooven L, Peres G, Tondoh JE, Cluzeau D, Brun J-J
greater degree of weight loss is seen when initiating from a higher starting weight [42]
Putting the evidence side by side Here is the blunt comparison: AOD 9604: 2.6 kg weight loss in 12 weeks (best result), failed six clinical trials, development terminated Semaglutide: 15 to 17 percent body weight loss over 68 weeks, FDA approved, thousands of study participants, consistent results across multiple trials There is no way to frame this comparison that puts AOD 9604 on equal footing with semaglutide when it comes to clinical evidence
Glucocorticoid antagonists can reduce these levels, indicating that controlling the HPA axis can improve depression (315)
Wegovy, which contains semaglutide as its active ingredient, is specifically designed for chronic weight management
However, human evidence is limited, largely extrapolated from small or observational studies