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Contraindications for investigational use should be discussed with a healthcare provider and may include Wilsons disease (a copper accumulation disorder), pregnancy (no data), or known allergy to copper/peptides

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However, since IL-6 can cross the blood-brain barrier [67], the significant IL-6 sera levels determined at the first visit of ALS patients might have been abrogated at the second visit due to infiltration of this protein per se in addition to extravasation of inflammatory cells into the CNS parenchyma

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(2016) 311:C386C91