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Clinical trial data and FDA labeling information indicate that gastrointestinal effects are dose-dependent and typically most pronounced during initial treatment or dose escalation

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Kremer, Breier, Risau, Plate, "Up-regulation of flk-1 /vascular endothelial growth factor receptor 2 by its ligand in a cerebral slice culture system," Cancer Res., 57:3852- 3859, 1997