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New insights and new approaches for the treatment of essential hypertension: selection of therapy based on coronary heart disease risk factor analysis, hemodynamics profiles, quality of life, and subsets of hypertension

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This effect was mediated by the upregulation of PKA/CREB signaling and the downregulation of the Notch/Hes-1 pathway, leading to enhanced peroxisome proliferator-activated receptor coactivator 1 expression, thus improving gentamicin-induced renal injury in rats (115)