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Its sequence contains two cysteine residues that form a disulfide bridge, giving the fragment a constrained loop structure important for its activity

In this test, animals could explore all three arms freely (Additional file 1: Figure S1A)

The original genetic-validation study used antisense oligonucleotide-mediated knockdown of NNMT in adipose tissue of mice on a high-fat diet, with whole-body and adipose-tissue metabolic endpoints measured against scrambled-oligonucleotide controls [2]

For more details, please refer to the manual: Handling and Storage of Synthetic Peptides References Pollard JD, Quan S, Kang T, Koch RJ

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