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Gastrointestinal Burden GLP-1 receptor agonists slow gastric emptying and directly act on the GI tract which is why nausea, vomiting, constipation, and diarrhoea are among the most commonly reported side effects, especially during dose escalation

These effects highlight the importance of monitoring your bodys responses closely when starting the medication or adjusting the dose

This creates an interesting mechanistic distinction

The most evidence-based approach is to use a GLP-1 medication for appetite regulation and weight loss, while supporting muscle preservation through adequate protein intake (at least 1.2 g per kg of body weight daily) and regular resistance training

32 How to Minimize Side Effects Fasting for a full 48 hours isnt easy, which is why Fernando recommends starting with shorter fasts

Guglielmetti M, Ferraris C, Tagliabue A, Frias-Toral E, Tavazzi E, La Malfa A, Greco G, Bergamaschi R, Zambrano-Villacres R, Godos J, Grosso G