The chemical mechanism by which glutathione -S- transferase is inactivated by the glutathione acrylate analog is likely based on the presence in the tertiary structure of the enzyme of a docking site where glutathione is bound and its free thiol group is deprotonated by a facing amino acid which acts as a strong proton acceptor [129]
doi: 10.3389/fnins.2020.601193 Received 31 August 2020 Accepted 04 November 2020 Published 08 December 2020 Volume 14 - 2020 Edited by John Zhang, Loma Linda University, United States Reviewed by Carmen Rubio, Instituto Nacional de Neurologa y Neurociruga Manuel Velasco Surez, Mexico
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Also high-valent chromium(VI) is able to generate reactive ROS during its conversion to the stable Cr 3+ oxidation state [13] and this mechanism has been associated to the recognized carcinogenic activity of chromate salts [14]
