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People with a hungry gut obesity subtype respond better to tirzepatide than others, while semaglutide is shown to reduce liver scarring and biological aging

Energy deficiency may be the leading cause of fatigue and intense hunger during the fasting period

NSAIDs such as ibuprofen (Advil, Motrin) can also help reduce inflammation, swelling and itching but patients should receive permission from their doctor to make sure these medications are safe with their current treatment

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Hypoglycaemia risk is increased when tirzepatide is used with insulin or sulfonylureas