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doi: 10.1210/endo.130.3.1537280 63 VujcicSLiangPDiegelmanPKramerDLPorterCW
As a result, a new ferroptosis inhibition axis with GTP cyclohydrolase-1 (GCH1) as the core was finally determined, which was found to be mainly regulated by the GCH1/BH4/DHFR pathway, which also protected cells from ferroptosis in a GPX4-independent manner ( Figure 1D )
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