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It penetrates the epidermis, reaches dermal fibroblasts, stimulates collagen synthesis, and modulates local gene expression

In our experiment of endothelium-dependent vasodilation, 10 9 10 7 mol/L acetylcholine (Ach) stimulation decreased the vascular tension of aortic rings in a dose-dependent manner in wild-type mice under normal diet condition (Fig

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At higher doses (above 3 grams per day), some individuals may experience mild gastrointestinal discomfort

LDN: The most common side effects are transient and often dose-dependent