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Limited data exists, but clinical trials suggest approximately 10-15% of people may be non-responders who dont achieve significant weight loss 5

"Lest we forget you methylene blue" (Neurobiol Aging, 2011) 4.FDA Compounding and the FDA: Questions and Answers (503A) 5.NIH MedlinePlus Methylene Blue (a682040)

Greater proportions of patients treated with WEGOVY injection achieved 5%, 10%, and 15% weight loss than those treated with placebo as shown in Table 10

This is why many evidence-based guidelines for fat loss recommend a pace that is relatively moderate rather than aggressive

If necessary, psychological support can be sought to help cope with these issues

Cold protein foods such as milk or calcium fortified plant milk, as well as yogurt, nuts, and seeds, are optimal choices, Luk explains