Rather than focusing solely on observable tissue changes, these investigations often seek to understand the molecular events that occur before structural adaptations become visible
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These metabolites are biologically active, can reduce intravascular oxidative stress, inhibit hepatocyte gluconeogenesis and oxidative stress, increase cardiomyocyte activity, promote vasodilation, protect the cardiovascular system, improve cardiac function, thereby directly or indirectly protecting the cardiovascular system ( 4.3 Nervous system disorder Recently, a protective effect of the GLP-1/GLP-1R axis on ischemic brain injury has been emphasized
Muscle mass preservation is an important consideration given the risk of sarcopenic obesity: weight loss with GLP-1 RAs includes a lean mass component (approximately 25%-40% of total weight loss), though the clinical significance in MASLD patients without sarcopenia is uncertain
Free radicals are unstable molecules that damage cells, proteins, and DNA