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The native peptide has limited blood-brain barrier penetration, which is part of why some recent research has focused on DSIP fusion peptides combined with cell-penetrating sequences (like Tat) to improve CNS delivery
Research protocols frequently align administration with natural GH-release windows, particularly an evening dose to coincide with the early-sleep GH pulse
For example, if a peptide has a half-life of 24 hours, roughly half of the compound may still remain after one day
Why GHK-Cu Works Better Systemically (Not Just Topically) While GHK-Cu is commonly found in serums and post-procedure products, systemic delivery allows it to work beyond the surface of the skin
How to Choose Which is Right for You For most people, the answer isn't "one or the other," but rather "how do I use them together?" However, your lifestyle can provide clues about where to start
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