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[42] A 2015 meta analysis found no increased risk from first trimester use in cohort studies that was a slight increase of malformations in case control studies

At the 52-week mark, average weight loss was 19.5% of total body weight

Storage conditions (typically 28C, protected from light) and beyond-use dates must follow the sponsor's validated stability data

Some are designed to influence appetite

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Strasser A, OConnor L, Dixit VM