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Whilst oral bioavailability is relatively poor (less than 5% reaches systemic circulation due to extensive first-pass metabolism), sufficient absorption occurs to produce measurable pharmacological effects in research settings

deuteriujm bonds are stronger than hydrogen bonds, resulting in a slower rate of metabolism, (slower clearance), and longer half life, which reduces the dosing rate from 3 times a day to 2 times a day (Schneider et al, 2021)

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Wing RR, Phelan S

Women with an MTHFR gene mutation may have a harder time processing folate, which could raise their risk of having a baby with spina bifida or other neural tube complications