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Avicenna J Phytomed

At the basolateral membrane, NBC1 (Na + -bicarbonate cotransporter 1: encoded by the SLC4A4 gene) effluxes HCO 3 , made de novo intracellularly via CAII, to the blood

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Consistent with the in vivo findings, Acsl4 knockout in mouse renal tubular epithelial cell lines (MTECs) resulted in decreased lipid peroxidation and mitigation of mitochondrial dysfunction, thus reducing calcium oxalate (CaOX)-induced ferroptosis

Values are normalized to the group without oxLDL loading