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Mutations in FXN lead to impaired ironsulfur cluster formation, triggering intracellular iron starvation responses that paradoxically result in mitochondrial iron overload, oxidative stress, and subsequent cellular dysfunction (386)

, Therefore, direct protective effects by GLP-1 receptor agonists acting through other mechanisms are likely

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NEJM, 2023

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Submitting intake information allows clinicians to review eligibility, but approval is not guaranteed at any stage of the process