When LH levels rise, LH and FSH work together to promote the production of progesterone and progesterone receptors in CGCs and to withdraw TZP from the oocyte membrane to the CGCs in preparation for the oocyte germinal vesicle to rupture (46, 47)
396 Metabolic disorders Overnutrition is a driving factor for obesity and related metabolic disorders, mainly including type 2 diabetes mellitus (T2DM), metabolic syndrome, nonalcoholic fatty liver disease (NAFLD), and polycystic ovarian syndrome (PCOS)
However, not everyone needs or tolerates the highest dosemany patients see excellent outcomes at 10 mg weekly or lower
Still, it is important for healthcare professionals to stay alert and for patients to report any changes they notice
Figure 9 In summary, through their customizable design, COF platforms not only overcome key limitations of conventional sensitizers-such as insufficient ROS generation, limited tissue penetration, and poor targeting-but also advance therapeutic paradigms from simple cell ablation to precisely inducing layered, immunogenic forms of cell death
doi: 10.1002/j.1939-4640.2000.tb02135.x 39 PasqualottoFFSharmaRKPottsJMNelsonDRThomasAJAgarwalA
