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Nrf2-Keap1 pathway-mediated effects of resveratrol on oxidative stress and apoptosis in hydrogen peroxide-treated rheumatoid arthritis fibroblast-like synoviocytes

Promising in animals, limited in humans

221 PERK, the most studied UPR sensor, activates ATF4, resulting in widespread transcriptional activation of genes engaged in diverse pathways, including metabolism, autophagy, and cell death programs

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What sets it apart is its long half-lifeit sticks around in the body longer than earlier compounds in this class, potentially allowing for more sustained effects