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There are concerns that GLP-1 receptor agonists may perform differently in real-world settings, compared to clinical trials

C.CroyalM.EneL.AguesseA.Billon-CrossouardS.KrempfM.et al (2019)

Side Effects and Tolerability Profiles Ozempic commonly produces gastrointestinal side effects during the first 4-8 weeks, including nausea, vomiting, diarrhea, and constipation

Certain peptides interact directly with melanocortin receptors in the brain

Generally speaking, the absorption efficiency after oral administration may be affected by the gastrointestinal environment, and different physiological states of the gastrointestinal tract may lead to differences in absorption rate and degree

doi: 10.1111/dom.13908 116 LaffertyRAGaultVAFlattPRIrwinN