Along with Choline, it aids in reducing liver fat and protects the kidneys
Oral bioavailability has not been characterized, and the compound's heptapeptide structure (773.89 Da) makes oral activity less likely than for the smaller Dihexa (504.66 Da), though not impossible given its modified sequence
Reconstitution protocol for the 60 mg vial Reconstitution is the single most important step
small aliquots stored at lower temperatures extend usable life
The AnglV analog D-Nle-Tyr-Ile-NH-(CH 2 ) s -CONH 2 has a much longer circulating half- life than Norleual (Nle-Tyr-Leu-i^CHj-NH^-His-Pro-Phe (SEQ ID NO: 1)) As anticipated from the in- vitro blood stability data, D-Nle-Tyr-Ile-NH-(CH 2 )5- CONH 2 exhibited an extended in vivo elimination half-life of 1012 min after IV injection in rats
In conclusion, we suggest the stable gastric pentadecapeptide BPC 157 as a useful oral peptide therapy against acute pancreatitis and the extensive presentation of adverse effects such as the shared occlusion-like syndrome
