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Quality and Strength of Injections: Injection ingredients might vary in quality and amount

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In the STEP trials, semaglutide was administered as part of a comprehensive lifestyle intervention that included a reduced-calorie diet (approximately 500 kcal/day deficit based on baseline energy requirements) and a minimum of 150 min of physical activity per week [38,39,40,41,42,43,44,45,46, 78, 97]

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Additional strategies to manage side effects: Eat smaller, more frequent meals rather than large portions Avoid high-fat, greasy, or spicy foods that may exacerbate nausea Stay well hydrated to prevent dehydration and potential kidney problems Eat slowly and stop when you feel comfortably full Consider ginger tea or other natural remedies for nausea (discuss with your pharmacist) When to seek medical advice: Contact your GP or healthcare provider if you experience: Severe, persistent vomiting that prevents adequate fluid intake Signs of dehydration (dark urine, dizziness, reduced urination) which may lead to acute kidney injury Severe abdominal pain , particularly if accompanied by vomiting (potential pancreatitis) Symptoms of hypoglycaemia if taking other diabetes medications Visual changes or eye symptoms , particularly if you have pre-existing diabetic retinopathy New or worsening mood changes , including thoughts of self-harm Persistent side effects that significantly affect your quality of life Rare but serious adverse effects include pancreatitis, gallbladder problems, and thyroid C-cell tumours (observed in animal studies, with uncertain relevance to humans)