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One of the reasons semaglutide is considered safe is the gradual increase in dosage, which helps minimize side effects and allows patients to adapt more comfortably

Caffeine, Hydration, and Nausea on Tirzepatide or Semaglutide Nausea is one of the most common side effects during the first 12 weeks of semaglutide or tirzepatide therapy, affecting up to 40% of patients starting treatment

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That matters even more when a person is using a GLP-1 medication and already noticing changes in appetite or digestion

But there are early signs that GLP-1s can make a difference at the population level