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Cycling protocols with appropriate off-periods are recommended to maintain sensitivity and reduce potential cumulative effects

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PubMed Brzoska, T., Bohm, M., Lugering, A., Loser, K., Luger, T.A

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Adults over 60 are more likely to have low levels of vitamin B12

These trials included both single-dose pharmacokinetic studies and long-term efficacy trials extending up to 24 weeks of continuous administration