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The cultured cochlear SGNs were treated with different doses of BAY11-7082 (5 M, 10 M and 20 M) and co-treated with 100 M peroxynitrite for 48 h
SIRT1 can deacetylate LKB1, an upstream regulator of AMPK, increasing the cytoplasmic localization of LKB1 and thus promoting AMPK activation
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Scientists believe the main culprits are the presence of hormone-disrupting chemicals in the environment, and lifestyle factors like diet and exercise
The series is active in vitro in the low nM range against 12 strains of P
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