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Furthermore, gasdermins, which regulate inflammatory form of cell death, were upregulated in the brains of GCLC-KO mice, suggesting the contribution of pyroptosis to neuronal cell death in these animals

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investigated the effect of EGCG on NASH by intraperitoneal injection and gavage, and found that the iron accumulation in the liver of mice fed by both methods was significantly lower than that of the NASH group, and the long-chain fatty acid coenzyme ACSBG expression was increased, with a significant negative correlation with Bacillus mimicus , a representative lineage organism genus of the intestinal microbiota (85)

Therapeutic interventions targeting ferroptosis are promising for the mitigation of its effects and improvement of pregnancy outcomes