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Constipation can occur because the drug signals the body to delay digestive processes

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A study published in JAMA Internal Medicine contrasting the effects of taking semaglutide and tirzepatideconsisting of both a GLP-1 receptor agonist and a gastric inhibitory polypeptideon patients with type 2 diabetes showed that tirzepatide has a greater impact on weight loss than semaglutide

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This commenter commended CMS's careful scrutiny, particularly in regard to the single-use endoscope application, and urged CMS to continue evidence-based evaluations