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doi: 10.1016/j.phymed.2021.153712 5

Reflecting on the clinical implications, St-Pierre says that the findings support cautious use of GLP-1 RAs in selected patients with IBD when prescribed for approved metabolic indications, with appropriate counselling and monitoring. At the same time, she noted that the findings highlight substantial evidence gaps and believes future research should move beyond proxy outcomes and incorporate prospective, IBD-specific designs that integrate objective inflammatory measures with robust metabolic phenotyping. Moreover, there should be special considerations on the effects of GLP-1 RAs on body composition of patients with IBD, she adds

This population-based, prospective, cohort study from the United Kingdom describes a dose-dependent, increased risk of myocardial infarction among patients with psoriasis

The mechanism of action of GLP-1r agonists and DPP-4 inhibitors includes islet - and -cell effects Effects of GLP-1r signaling on cardiovascular function are still under investigation but there is experimental evidence that this could be another beneficial component of pharmacology.

In laboratory models, the research compound retatrutide is believed to work by simultaneously influencing several metabolic signaling pathways

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