10.3920/BM2012.0046 Benef Microbes 207 TurnbaughP
The activation of hypothalamic neurons, suppression of food intake, and weight loss induced by liraglutide were attenuated in mice with impaired transcellular transport in tanycytes or in mice with a tanycyte-specific GLP-1 receptor knockdown [7]
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A second mechanism leading to hepatocellular hyperplasia is a consequence of shifts of existing hepatocyte populations from binucleated hepatocytes to mononucleated cells and shifts from a mononucleated tetraploid hepatocyte to two diploid hepatocytes (cytokinesis without nuclear duplication)