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Glucagon-like peptide-1 receptor agonists (GLP-1RAs), which are widely used for the treatment of T2DM and promote weight loss in individuals with obesity, have demonstrated significant cardiovascular benefits

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However, in an in vitro study using pasireotide, we considered the possibility of endogenous DPP-4 being present in GLUTag cells and added a DPP-4 inhibitor

10.1002/hep.32235 42 KimA.-R.JeonS.-G.ParkS.-J.HongH.KimB

In some, as the disease progresses, despite titration of the basal insulin to correct fasting hyperglycaemia (typically more than 0.5 U/kg), mealtime insulin may have to be added to meet glycaemic targets, particularly postprandial glucose [328]

thus, they are an attractive therapeutic option for patients with type 2 diabetes, especially those with existing cardiovascular disease or at high risk for those complications