Mir Ali, MD, is a bariatric surgeon and medical director of MemorialCare Surgical Weight Loss Center at Orange Coast Medical Center
We believed from the start that topical treatment with diclofenac would be useful in the treatment of PD, for its well-established painkilling and antiinflammatory properties, as well as its free-radical scavenging activity and action against the proinflammatory cytokine cascade, including factor NF-kB production
In the oral mucosa, where the ageing epithelial cells move faster to the surface compared to skin, a similar defence-mechanism seems to be present, cleaning the mucosa from different toxic chemicals penetrating the epithelium
These studies have contributed to understanding the potential role of NNMT in metabolic disorders
Clinical data show moderate improvement in pigment index, not dramatic shade changes
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