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To establish connection with the NO-system, L-NAME (5.0 mg/kg) (worsening) and L-arginine (200.0 mg/kg) (effective only with blunted NO-synthesis, but not alone) were given intraperitoneally alone or in combination (d-arginine 200.0 mg/kg was not effective, data not shown)

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Sec63p and Kar2p are required for the translocation of SRP-dependent precursors into the yeast endoplasmic reticulum in vivo

The pathway is well-characterized

Only one study tested caffeine alone, and even then, it compared caffeine to minoxidil rather than to a true control

Consistency matters more than anything