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Vomiting: High doses or use on an empty stomach increase stomach acidity and irritation, triggering nausea and vomiting

From a biological standpoint, Tirzepatide is a dual agonist (initiates physiologic response) that targets both the GLP-1 and glucagon receptors, while Semaglutide is a single GLP-1 receptor agonist

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That includes shifts in period timing, flow, PMS symptoms, and even ovulation patterns