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Biochemistry 35 , 44454456, doi: 10.1021/bi9521093 (1996)
This glucose-dependent mechanism is the reason semaglutide, when used as a monotherapy, carries a very low risk of causing hypoglycemia (dangerously low blood sugar)
They may start avoiding places, activities, or situations because they worry an attack may happen again
It accomplishes this by simultaneously targeting three hormone pathways that regulate appetite and metabolism, causing people to feel less hungry and burn more calories
They may also stimulate receptors in the gut and brain to reduce chronic inflammation