2016 meta-analysis: Nine RCTs in 911 participants found carnitine supplementation resulted in 1.33 kg more weight loss than placebo [3][63]
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However, more recent studies assessing the role of ferrous iron in the pathophysiology first in vitro [74, 75] and then in vivo [76, 77] provided evidence that after a toxic dose of APAP ferrous iron derived from lysosomes is taken up into mitochondria through a Ca 2+ uniporter and facilitates the MPTP opening and cell death
Materials and methods A systematic search was conducted in the international scientific databases, including PubMed, Embase, Web of Science, Scopus and Cochrane Central Library, for relevant studies published up to September 2021
