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In male mice, supplementation with folic acid, vitamin B6 + B12, choline, methionine and zinc (P2-P9) reversed POS-induced cognitive deficits in the MWM and the ORT, but not the OLT at four months of age [15]

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In contrast to the highly permeable vasculature in peripheral organs, adjacent ECs in the brain are characterized by high trans-endothelial electrical resistance (TEER), low rates of transcytosis, and restricted paracellular permeability, which is primarily governed by junctional molecules [12]

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