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Body and organ weights are presented in Table I

Doses were 25, 50 and 200 mg/kg in rats and 25, 50 and 100 mg/kg in rabbits which are approximately 0.3, 0.6 and 2-times (rats) and 0.6, 1 and 2-times (rabbits) the MRHD for schizophrenia of 800 mg/day based on mg/m2 body surface area

Challenges and Considerations While genetic testing offers numerous benefits, it is not without challenges

Published April 3, 2020

Given the poorly characterized specificity of enzymes involved in thiamine transformation and the often unknown roles of genomics-identified isoenzymes, all human isoenzymes are included in Figure 3 when there is evidence that at least one isoenzyme can catalyze the reactions with thiamine or its derivatives

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