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This adipose tissue accumulation is notably resistant to conventional weight loss strategies and is frequently associated with joint hypermobility.7,12 Symptoms often worsen throughout the day, particularly with heat exposure or prolonged standing, and are commonly accompanied by sensations of heaviness, tenderness, and discomfort in the affected areas.10,20 Notably, the S2k Guidelines emphasize that a disproportionate increase of adipose tissue on the extremities without corresponding symptoms shall not be diagnosed as lipedema

24 months

Room temperature exposure limits Brief periods at room temperature during dose drawing are perfectly fine

Insomnia is not listed as an adverse reaction in the MHRA Summary of Product Characteristics, though some patients report sleep disturbances

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