56 Autophagy mediates the recycling of AGES and other defective proteins and an age-related reduction in autophagic activity in dermal fibroblasts is found to reduce collagen, hyaluronan, and elastin, collectively leading to deterioration of dermal integrity and skin fragility
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In fact, our own analysis of long-read sequencing from target-specific natively paired and combinatorial libraries supports this observation and suggests that a sizable fraction of a natively-paired library is, in fact, mispairings between promiscuous antibody chains
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IM administration is the most invasive and costly, requiring healthcare visits, trained personnel, and procedural infrastructure