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BMAL1 forms heterodimers with CLOCK to drive the transcription of core clock-controlled genes such as PERS, CRYS and DBP (Mendoza-Viveros et al., 2017), and consistently, HRD1 overexpression significantly reduces PER1 and DBP mRNA levels, suggesting downstream transcriptional suppression via BMAL1 destabilization (Guo et al., 2020)
The copper-peptide complex degrades rapidly above 8C and oxidizes when exposed to air or UV light
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