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RIBBON-2: A randomized, double-blind, placebo-controlled, phase III trial evaluating the efficacy and safety of bevacizumab in combination with chemotherapy for second-line treatment of human epidermal growth factor receptor 2-negative metastatic breast cancer

Proc Natl Acad Sci U S A , 115 (16), 40754080

At steady state, single deviations such as a missed or double dose, a dose with shorter (15 min) or longer (120 min) post-dose fasting time or a dose taken with a larger volume of water (240 mL) will result in only minor and transient changes in exposure

This method is designed to maintain product integrity and allows vials to remain stable during shipping for approximately 34 months

Arch Neurol 212AD

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