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The expansion of mesenchymal-like population at Day 45 suggests that these organoids could serve as an advanced model for studying fibrogenesis and testing anti-fibrotic therapies 34

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Increases in resting heart rate are a recognised class effect of incretin-based therapies and have been reported with GLP-1 receptor agonists more broadly, as reflected in the Summary of Product Characteristics (SmPC) for licensed agents such as semaglutide (Wegovy) and liraglutide (Saxenda)