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Thus, NOs dual nature, with its tumor-promoting effects at low levels and cytotoxic effects at higher levels, presents both challenges and opportunities for CRC therapy (3739)

ROS are directly or indirectly associated with cytokine storm induction in SARS-CoV-2 infection, and ROS can activate NF-B and NLRP3 inflammasomes, thereby leading to the production of inflammatory cytokines and the development of acute respiratory distress syndrome and multiple organ dysfunction 62,63,64

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