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[24] [25] According to the FDA prescribing information, gastrointestinal adverse reactions are dose-dependent and typically occur during dose escalation

This side effect is often most noticeable when first starting treatment or after a dose increase, which is why most protocols begin at a lower dose and increase gradually over time

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Start your intake How Semaglutide Affects Stomach and Bowel Function Semaglutide works by binding to GLP-1 receptors throughout the gastrointestinal tract, signaling the stomach to empty more slowly and the brain to feel fuller with smaller meals