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In the CARMELINA trial, the scientists looked at how linagliptin performed versus a placebo (no drug) in the CAROLINA study: linagliptin vs

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Weight loss itselftypically 1015% of baseline body weight over 6 monthsfurther reduces triglyceride burden by decreasing visceral fat and hepatic lipid accumulation

Gradual dose titration, as recommended in the Summary of Product Characteristics, helps minimise gastrointestinal disturbance

Common side effects are increased urination and thirst, constipation, and nausea