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A metabolome analysis disclosed that sulphasalazine triggers an increase in the glutamate-derived TCA cycle intermediate -ketoglutarate in addition to a decrease in cysteine and glutathione

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Brain Research Bulletin 69 (3): 327331

This form of methylfolate can boost glutathione levels and bypasses folate insufficiency due to MTHFR deficiency, entering the folate cycle directly without the need for further enzymatic modification

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