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Additionally, some GLP-1s are approved for weight management in adults who meet BMI criteria with or without another metabolic dysfunction (like high blood pressure, diabetes, or high cholesterol)

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CagriSema treatment resulted in substantially greater and clinically meaningful weight loss (-20.4%) than semaglutide alone (-14.9%), cagrilintide alone (-11.5%), or placebo (-3.0%), a finding consistent with at least partial additivity, although the study design does not permit a formal assessment of additive or synergistic effects

It works by mimicking the action of GLP-1, a naturally occurring hormone that regulates appetite and food intake

Tirzepatide and SGLT2i should be avoided, due to the secretory effect on glucagon secretion induced by both GIP and glifozins [148, 149]

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