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10.1016/j.abb.2015.06.024 Arch Biochem Biophys

The idea that restoring them to more youthful levels could keep the brain more flexible (sharper, more open to learn, with a better memory) has long interested scientists

Channel-closure figures come from human and in vitro models and vary with needle length, occlusion, and individual skin

May 2012;44(2):148-172

This is one of the strongest arguments for staying at or near the 100 mcg per injection saturation dose rather than escalating higher

Biologics like anti-tumor necrosis factor-alpha (TNF-) agents are more effective, with response rates of 60 - 70% of cases, but increase infection risks and are cost-prohibitive (6)